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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL5
All Species:
5.45
Human Site:
S641
Identified Species:
15
UniProt:
O76039
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76039
NP_001032420.1
1030
115538
S641
G
M
A
A
R
A
N
S
L
Q
L
L
S
P
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
NP_001129485
570
64691
S206
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
Dog
Lupus familis
XP_548881
960
107395
F592
L
S
A
P
H
E
S
F
S
Y
G
L
G
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
Q3UTQ8
938
105471
P574
T
M
E
E
L
K
L
P
E
H
M
D
S
S
H
Rat
Rattus norvegicus
Q5XIT0
507
57117
C143
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514328
967
107039
P592
H
S
H
S
L
S
A
P
H
E
S
F
S
Y
G
Chicken
Gallus gallus
XP_425571
960
107495
S593
S
A
P
H
E
S
F
S
Y
G
L
G
Y
T
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001124243
1039
116666
S665
G
V
P
T
R
A
S
S
L
Q
L
L
S
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796071
627
72401
I263
E
I
D
Q
L
Y
M
I
Q
K
I
L
G
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
26.7
88.1
N.A.
85.9
23.6
N.A.
76.5
75.2
N.A.
55.3
N.A.
N.A.
N.A.
N.A.
25.5
Protein Similarity:
100
N.A.
39.5
89.7
N.A.
88.9
36.5
N.A.
82.5
83.6
N.A.
69.1
N.A.
N.A.
N.A.
N.A.
39
P-Site Identity:
100
N.A.
6.6
13.3
N.A.
13.3
0
N.A.
6.6
13.3
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
13.3
20
N.A.
20
6.6
N.A.
26.6
20
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
23
12
0
23
12
0
0
0
0
0
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
0
0
0
12
0
23
0
12
12
0
0
0
% D
% Glu:
23
0
12
12
12
12
0
0
12
12
0
0
0
0
0
% E
% Phe:
0
0
0
12
0
0
12
12
0
12
0
23
0
0
0
% F
% Gly:
23
0
12
0
0
12
0
0
0
12
23
12
23
0
12
% G
% His:
12
0
12
12
12
0
0
0
12
12
0
0
0
0
23
% H
% Ile:
0
12
0
0
0
0
0
12
0
12
12
0
0
0
0
% I
% Lys:
0
0
0
0
0
23
0
0
0
12
0
0
0
0
0
% K
% Leu:
12
0
12
0
34
0
23
0
23
0
34
45
12
0
12
% L
% Met:
0
23
0
0
0
0
12
0
0
0
12
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% N
% Pro:
0
12
23
12
12
0
0
23
0
0
0
0
0
34
0
% P
% Gln:
12
0
0
12
0
0
0
0
12
23
0
12
0
0
23
% Q
% Arg:
0
0
0
0
23
0
0
0
0
0
0
0
0
12
0
% R
% Ser:
12
34
0
12
0
23
23
45
12
0
12
0
45
12
12
% S
% Thr:
12
0
0
12
0
0
0
0
0
0
0
0
0
12
23
% T
% Val:
0
12
0
12
12
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
12
12
0
0
12
34
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _